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Protein
Design

List curated protein design specifications

GET/compute/v1/protein/design/curated-specifications

List binder-side protein design specifications from Boltz-managed curated nanobody or antibody libraries.

Query ParametersExpand Collapse
type: "nanobody" or "antibody"

Curated binder library to retrieve.

One of the following:
"nanobody"
"antibody"
ReturnsExpand Collapse
data: array of object { binder_specification, name }
binder_specification: object { chain_selection, modality, structure, 2 more } or object { entities, modality, type, 2 more } or object { binder, type, rules } or object { binder_specifications, type }

Binder specification for protein design. Use no_template for sequence-defined binders, structure_template for uploaded binder structures, boltz_curated for Boltz-managed nanobody and antibody defaults, or uniformly_sampled_specifications to sample uniformly across multiple binder specifications.

One of the following:
StructureTemplateBinderSpec object { chain_selection, modality, structure, 2 more }

Binder specification starting from an existing 3D structure. Upload a CIF/PDB file and select which chains to include, which residues to keep, and which regions to redesign. Only chains included in chain_selection are part of the pipeline run.

chain_selection: map[object { chain_type, crop_residues, design_motifs } or object { chain_type } ]

Chains selected from the uploaded binder structure, keyed by chain ID. Only chains listed here are included in the pipeline run — any chains omitted from this mapping are ignored. Each value defines which residues to keep (crop_residues). Omit design_motifs to include the chain as fixed scaffold context.

One of the following:
StructureTemplatePolymerChainSpec object { chain_type, crop_residues, design_motifs }

Per-chain crop and design specification for a polymer chain in structure_template mode.

chain_type: "polymer"
crop_residues: array of number or "all"

0-indexed residue indices to retain from this chain, or ‘all’ to keep all residues. Residues not listed are removed before design.

One of the following:
array of number
"all"
design_motifs: optional array of object { design_length_range, end_index, start_index, type } or object { after_residue_index, design_length_range, type }

Optional motifs (replacement or insertion) defining which regions to redesign on this chain. Omit this field to include the chain as fixed scaffold context.

One of the following:
ReplacementMotif object { design_length_range, end_index, start_index, type }

Replace a contiguous region of the sequence with a designed segment. Residues from start_index to end_index (inclusive) are replaced with a new sequence of the specified length.

design_length_range: object { max, min }

Allowed sequence length range for designed regions

max: number

Maximum sequence length in residues. Must be >= min.

minimum0
min: number

Minimum sequence length in residues

minimum0
end_index: number

0-indexed end residue (inclusive)

minimum0
start_index: number

0-indexed start residue (inclusive)

minimum0
type: "replacement"
InsertionMotif object { after_residue_index, design_length_range, type }

Insert a designed segment at a specific position in the sequence.

after_residue_index: number

0-indexed position after which to insert. Use -1 to insert before the first residue.

minimum-1
design_length_range: object { max, min }

Allowed sequence length range for designed regions

max: number

Maximum sequence length in residues. Must be >= min.

minimum0
min: number

Minimum sequence length in residues

minimum0
type: "insertion"
StructureTemplateLigandChainSpec object { chain_type }

Per-chain specification for a ligand chain in structure_template mode. The full ligand is always included.

chain_type: "ligand"
modality: "peptide" or "antibody" or "nanobody" or "custom_protein"
One of the following:
"peptide"
"antibody"
"nanobody"
"custom_protein"
structure: object { type, url } or object { data, media_type, type }

How to provide a CIF structure file. URLs are auto-detected; base64 uploads must use chemical/x-cif media type.

One of the following:
URLSource object { type, url }
type: "url"
url: string
formaturi
CifBase64Source object { data, media_type, type }
data: string

Base64-encoded CIF file contents

media_type: "chemical/x-cif"

Must be chemical/x-cif for CIF files

type: "base64"
type: "structure_template"
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction }

Constraints applied during sequence design

excluded_amino_acids: optional array of string

Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)

excluded_sequence_motifs: optional array of string

Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. “NGS”, “NXS”).

max_hydrophobic_fraction: optional number

Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable.

minimum0
maximum1
NoTemplateBinderSpec object { entities, modality, type, 2 more }

Binder specification without a structural template. Define the binder from sequence components (fixed and designed segments) without providing a starting 3D structure.

entities: array of object { chain_ids, type, value, 2 more } or object { chain_ids, type, value, 2 more } or object { chain_ids, type, value, 2 more } or 3 more

Binder entities composing the design. At least one must be a designed_protein entity. Additional fixed entities (RNA, DNA, ligands) can be included as part of the complex.

One of the following:
DesignedProteinEntity object { chain_ids, type, value, 2 more }

Protein binder entity with designed and/or fixed segments.

chain_ids: array of string

Chain IDs to assign to this entity

type: "designed_protein"
value: string

Binder sequence specification. Fixed amino acids are written as literal single-letter codes. Designed regions are written as a length (fixed) or a length range (min..max). Example: “MKTAYI5..10VKSHFSRQ” means fixed MKTAYI, then 5-10 designed residues, then fixed VKSHFSRQ. “20” means 20 fully designed residues. “ACDE8GHI” means fixed ACDE, then 8 designed residues, then fixed GHI.

cyclic: optional boolean

Whether the sequence is cyclic

modifications: optional array of object { residue_index, type, value }

Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported.

residue_index: number

0-based index of the residue to modify

minimum0
type: "ccd"

Modification format. Only CCD polymer modifications are supported.

value: string

CCD code from RCSB PDB (e.g. ‘MSE’ for selenomethionine, ‘SEP’ for phosphoserine)

FixedProteinEntity object { chain_ids, type, value, 2 more }

A fixed protein entity whose sequence is not redesigned.

chain_ids: array of string

Chain IDs to assign to this entity

type: "protein"
value: string

Amino acid sequence (one-letter codes)

cyclic: optional boolean

Whether the sequence is cyclic

modifications: optional array of object { residue_index, type, value }

Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported.

residue_index: number

0-based index of the residue to modify

minimum0
type: "ccd"

Modification format. Only CCD polymer modifications are supported.

value: string

CCD code from RCSB PDB (e.g. ‘MSE’ for selenomethionine, ‘SEP’ for phosphoserine)

FixedRnaEntity object { chain_ids, type, value, 2 more }
chain_ids: array of string

Chain IDs to assign to this entity

type: "rna"
value: string

RNA nucleotide sequence (A, C, G, U, N)

cyclic: optional boolean

Whether the sequence is cyclic

modifications: optional array of object { residue_index, type, value }

Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported.

residue_index: number

0-based index of the residue to modify

minimum0
type: "ccd"

Modification format. Only CCD polymer modifications are supported.

value: string

CCD code from RCSB PDB (e.g. ‘MSE’ for selenomethionine, ‘SEP’ for phosphoserine)

FixedDnaEntity object { chain_ids, type, value, 2 more }
chain_ids: array of string

Chain IDs to assign to this entity

type: "dna"
value: string

DNA nucleotide sequence (A, C, G, T, N)

cyclic: optional boolean

Whether the sequence is cyclic

modifications: optional array of object { residue_index, type, value }

Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported.

residue_index: number

0-based index of the residue to modify

minimum0
type: "ccd"

Modification format. Only CCD polymer modifications are supported.

value: string

CCD code from RCSB PDB (e.g. ‘MSE’ for selenomethionine, ‘SEP’ for phosphoserine)

FixedLigandSmilesEntity object { chain_ids, type, value }
chain_ids: array of string

Chain IDs to assign to this entity

type: "ligand_smiles"
value: string

SMILES string representing the ligand

FixedLigandCcdEntity object { chain_ids, type, value }
chain_ids: array of string

Chain IDs to assign to this entity

type: "ligand_ccd"
value: string

CCD code from RCSB PDB (e.g. ‘ATP’, ‘ADP’)

modality: "peptide" or "antibody" or "nanobody" or "custom_protein"
One of the following:
"peptide"
"antibody"
"nanobody"
"custom_protein"
type: "no_template"
bonds: optional array of object { atom1, atom2 }

Covalent bond constraints between atoms in the binder complex. If defining bonds where an atom is part of a designed protein chain, assume residue indices count designed regions as the minimum length. Example: designed protein “1..3C1..2”, “C” is residue 1 (0-indexed) of the designed protein.

atom1: object { atom_name, chain_id, type } or object { atom_name, chain_id, residue_index, type }

Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom.

One of the following:
LigandAtom object { atom_name, chain_id, type }

Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom.

atom_name: string

Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters.

chain_id: string

Chain ID containing the atom

type: "ligand_atom"
PolymerAtom object { atom_name, chain_id, residue_index, type }
atom_name: string

Standardized atom name (verifiable in CIF file on RCSB)

chain_id: string

Chain ID containing the atom

residue_index: number

0-based residue index

minimum0
type: "polymer_atom"
atom2: object { atom_name, chain_id, type } or object { atom_name, chain_id, residue_index, type }

Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom.

One of the following:
LigandAtom object { atom_name, chain_id, type }

Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom.

atom_name: string

Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters.

chain_id: string

Chain ID containing the atom

type: "ligand_atom"
PolymerAtom object { atom_name, chain_id, residue_index, type }
atom_name: string

Standardized atom name (verifiable in CIF file on RCSB)

chain_id: string

Chain ID containing the atom

residue_index: number

0-based residue index

minimum0
type: "polymer_atom"
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction }

Constraints applied during sequence design

excluded_amino_acids: optional array of string

Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)

excluded_sequence_motifs: optional array of string

Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. “NGS”, “NXS”).

max_hydrophobic_fraction: optional number

Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable.

minimum0
maximum1
BoltzCuratedBinderSpec object { binder, type, rules }

Boltz-managed curated binder specification. Choose a curated nanobody or antibody family and Boltz will select from maintained template lists during design. The curated lists are managed by Boltz and may be updated over time to improve quality and coverage.

binder: "boltz_nanobody" or "boltz_antibody"

Boltz-managed curated binder family. Boltz maintains and may update the underlying template lists on behalf of customers.

One of the following:
"boltz_nanobody"
"boltz_antibody"
type: "boltz_curated"
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction }

Constraints applied during sequence design

excluded_amino_acids: optional array of string

Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)

excluded_sequence_motifs: optional array of string

Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. “NGS”, “NXS”).

max_hydrophobic_fraction: optional number

Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable.

minimum0
maximum1
UniformlySampledBinderSpec object { binder_specifications, type }

A collection of binder specifications sampled uniformly during protein design. This lets one run explore multiple binder definitions while keeping each generation request shape unchanged.

binder_specifications: array of object { chain_selection, modality, structure, 2 more } or object { entities, modality, type, 2 more } or object { binder, type, rules }

Binder specifications to sample uniformly when generating designs. Each generation samples one specification from this list; over larger runs this gives roughly equal representation.

One of the following:
StructureTemplateBinderSpec object { chain_selection, modality, structure, 2 more }

Binder specification starting from an existing 3D structure. Upload a CIF/PDB file and select which chains to include, which residues to keep, and which regions to redesign. Only chains included in chain_selection are part of the pipeline run.

chain_selection: map[object { chain_type, crop_residues, design_motifs } or object { chain_type } ]

Chains selected from the uploaded binder structure, keyed by chain ID. Only chains listed here are included in the pipeline run — any chains omitted from this mapping are ignored. Each value defines which residues to keep (crop_residues). Omit design_motifs to include the chain as fixed scaffold context.

One of the following:
StructureTemplatePolymerChainSpec object { chain_type, crop_residues, design_motifs }

Per-chain crop and design specification for a polymer chain in structure_template mode.

chain_type: "polymer"
crop_residues: array of number or "all"

0-indexed residue indices to retain from this chain, or ‘all’ to keep all residues. Residues not listed are removed before design.

One of the following:
array of number
"all"
design_motifs: optional array of object { design_length_range, end_index, start_index, type } or object { after_residue_index, design_length_range, type }

Optional motifs (replacement or insertion) defining which regions to redesign on this chain. Omit this field to include the chain as fixed scaffold context.

One of the following:
ReplacementMotif object { design_length_range, end_index, start_index, type }

Replace a contiguous region of the sequence with a designed segment. Residues from start_index to end_index (inclusive) are replaced with a new sequence of the specified length.

design_length_range: object { max, min }

Allowed sequence length range for designed regions

max: number

Maximum sequence length in residues. Must be >= min.

minimum0
min: number

Minimum sequence length in residues

minimum0
end_index: number

0-indexed end residue (inclusive)

minimum0
start_index: number

0-indexed start residue (inclusive)

minimum0
type: "replacement"
InsertionMotif object { after_residue_index, design_length_range, type }

Insert a designed segment at a specific position in the sequence.

after_residue_index: number

0-indexed position after which to insert. Use -1 to insert before the first residue.

minimum-1
design_length_range: object { max, min }

Allowed sequence length range for designed regions

max: number

Maximum sequence length in residues. Must be >= min.

minimum0
min: number

Minimum sequence length in residues

minimum0
type: "insertion"
StructureTemplateLigandChainSpec object { chain_type }

Per-chain specification for a ligand chain in structure_template mode. The full ligand is always included.

chain_type: "ligand"
modality: "peptide" or "antibody" or "nanobody" or "custom_protein"
One of the following:
"peptide"
"antibody"
"nanobody"
"custom_protein"
structure: object { type, url } or object { data, media_type, type }

How to provide a CIF structure file. URLs are auto-detected; base64 uploads must use chemical/x-cif media type.

One of the following:
URLSource object { type, url }
type: "url"
url: string
formaturi
CifBase64Source object { data, media_type, type }
data: string

Base64-encoded CIF file contents

media_type: "chemical/x-cif"

Must be chemical/x-cif for CIF files

type: "base64"
type: "structure_template"
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction }

Constraints applied during sequence design

excluded_amino_acids: optional array of string

Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)

excluded_sequence_motifs: optional array of string

Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. “NGS”, “NXS”).

max_hydrophobic_fraction: optional number

Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable.

minimum0
maximum1
NoTemplateBinderSpec object { entities, modality, type, 2 more }

Binder specification without a structural template. Define the binder from sequence components (fixed and designed segments) without providing a starting 3D structure.

entities: array of object { chain_ids, type, value, 2 more } or object { chain_ids, type, value, 2 more } or object { chain_ids, type, value, 2 more } or 3 more

Binder entities composing the design. At least one must be a designed_protein entity. Additional fixed entities (RNA, DNA, ligands) can be included as part of the complex.

One of the following:
DesignedProteinEntity object { chain_ids, type, value, 2 more }

Protein binder entity with designed and/or fixed segments.

chain_ids: array of string

Chain IDs to assign to this entity

type: "designed_protein"
value: string

Binder sequence specification. Fixed amino acids are written as literal single-letter codes. Designed regions are written as a length (fixed) or a length range (min..max). Example: “MKTAYI5..10VKSHFSRQ” means fixed MKTAYI, then 5-10 designed residues, then fixed VKSHFSRQ. “20” means 20 fully designed residues. “ACDE8GHI” means fixed ACDE, then 8 designed residues, then fixed GHI.

cyclic: optional boolean

Whether the sequence is cyclic

modifications: optional array of object { residue_index, type, value }

Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported.

residue_index: number

0-based index of the residue to modify

minimum0
type: "ccd"

Modification format. Only CCD polymer modifications are supported.

value: string

CCD code from RCSB PDB (e.g. ‘MSE’ for selenomethionine, ‘SEP’ for phosphoserine)

FixedProteinEntity object { chain_ids, type, value, 2 more }

A fixed protein entity whose sequence is not redesigned.

chain_ids: array of string

Chain IDs to assign to this entity

type: "protein"
value: string

Amino acid sequence (one-letter codes)

cyclic: optional boolean

Whether the sequence is cyclic

modifications: optional array of object { residue_index, type, value }

Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported.

residue_index: number

0-based index of the residue to modify

minimum0
type: "ccd"

Modification format. Only CCD polymer modifications are supported.

value: string

CCD code from RCSB PDB (e.g. ‘MSE’ for selenomethionine, ‘SEP’ for phosphoserine)

FixedRnaEntity object { chain_ids, type, value, 2 more }
chain_ids: array of string

Chain IDs to assign to this entity

type: "rna"
value: string

RNA nucleotide sequence (A, C, G, U, N)

cyclic: optional boolean

Whether the sequence is cyclic

modifications: optional array of object { residue_index, type, value }

Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported.

residue_index: number

0-based index of the residue to modify

minimum0
type: "ccd"

Modification format. Only CCD polymer modifications are supported.

value: string

CCD code from RCSB PDB (e.g. ‘MSE’ for selenomethionine, ‘SEP’ for phosphoserine)

FixedDnaEntity object { chain_ids, type, value, 2 more }
chain_ids: array of string

Chain IDs to assign to this entity

type: "dna"
value: string

DNA nucleotide sequence (A, C, G, T, N)

cyclic: optional boolean

Whether the sequence is cyclic

modifications: optional array of object { residue_index, type, value }

Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported.

residue_index: number

0-based index of the residue to modify

minimum0
type: "ccd"

Modification format. Only CCD polymer modifications are supported.

value: string

CCD code from RCSB PDB (e.g. ‘MSE’ for selenomethionine, ‘SEP’ for phosphoserine)

FixedLigandSmilesEntity object { chain_ids, type, value }
chain_ids: array of string

Chain IDs to assign to this entity

type: "ligand_smiles"
value: string

SMILES string representing the ligand

FixedLigandCcdEntity object { chain_ids, type, value }
chain_ids: array of string

Chain IDs to assign to this entity

type: "ligand_ccd"
value: string

CCD code from RCSB PDB (e.g. ‘ATP’, ‘ADP’)

modality: "peptide" or "antibody" or "nanobody" or "custom_protein"
One of the following:
"peptide"
"antibody"
"nanobody"
"custom_protein"
type: "no_template"
bonds: optional array of object { atom1, atom2 }

Covalent bond constraints between atoms in the binder complex. If defining bonds where an atom is part of a designed protein chain, assume residue indices count designed regions as the minimum length. Example: designed protein “1..3C1..2”, “C” is residue 1 (0-indexed) of the designed protein.

atom1: object { atom_name, chain_id, type } or object { atom_name, chain_id, residue_index, type }

Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom.

One of the following:
LigandAtom object { atom_name, chain_id, type }

Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom.

atom_name: string

Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters.

chain_id: string

Chain ID containing the atom

type: "ligand_atom"
PolymerAtom object { atom_name, chain_id, residue_index, type }
atom_name: string

Standardized atom name (verifiable in CIF file on RCSB)

chain_id: string

Chain ID containing the atom

residue_index: number

0-based residue index

minimum0
type: "polymer_atom"
atom2: object { atom_name, chain_id, type } or object { atom_name, chain_id, residue_index, type }

Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom.

One of the following:
LigandAtom object { atom_name, chain_id, type }

Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom.

atom_name: string

Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters.

chain_id: string

Chain ID containing the atom

type: "ligand_atom"
PolymerAtom object { atom_name, chain_id, residue_index, type }
atom_name: string

Standardized atom name (verifiable in CIF file on RCSB)

chain_id: string

Chain ID containing the atom

residue_index: number

0-based residue index

minimum0
type: "polymer_atom"
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction }

Constraints applied during sequence design

excluded_amino_acids: optional array of string

Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)

excluded_sequence_motifs: optional array of string

Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. “NGS”, “NXS”).

max_hydrophobic_fraction: optional number

Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable.

minimum0
maximum1
BoltzCuratedBinderSpec object { binder, type, rules }

Boltz-managed curated binder specification. Choose a curated nanobody or antibody family and Boltz will select from maintained template lists during design. The curated lists are managed by Boltz and may be updated over time to improve quality and coverage.

binder: "boltz_nanobody" or "boltz_antibody"

Boltz-managed curated binder family. Boltz maintains and may update the underlying template lists on behalf of customers.

One of the following:
"boltz_nanobody"
"boltz_antibody"
type: "boltz_curated"
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction }

Constraints applied during sequence design

excluded_amino_acids: optional array of string

Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)

excluded_sequence_motifs: optional array of string

Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. “NGS”, “NXS”).

max_hydrophobic_fraction: optional number

Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable.

minimum0
maximum1
type: "uniformly_sampled_specifications"
name: string

Human-readable name for this curated binder specification.

List curated protein design specifications

curl https://api.boltz.bio/compute/v1/protein/design/curated-specifications \
    -H "x-api-key: $BOLTZ_API_KEY"
{
  "data": [
    {
      "binder_specification": {
        "chain_selection": {
          "B": {
            "chain_type": "polymer",
            "crop_residues": [
              0,
              1,
              2,
              3,
              4,
              5,
              6,
              7,
              8,
              9
            ],
            "design_motifs": [
              {
                "design_length_range": {
                  "max": 8,
                  "min": 4
                },
                "end_index": 5,
                "start_index": 0,
                "type": "replacement"
              }
            ]
          }
        },
        "modality": "peptide",
        "structure": {
          "type": "url",
          "url": "https://example.com"
        },
        "type": "structure_template",
        "rules": {
          "excluded_amino_acids": [
            "x"
          ],
          "excluded_sequence_motifs": [
            "string"
          ],
          "max_hydrophobic_fraction": 0
        }
      },
      "name": "name"
    }
  ]
}
Returns Examples
{
  "data": [
    {
      "binder_specification": {
        "chain_selection": {
          "B": {
            "chain_type": "polymer",
            "crop_residues": [
              0,
              1,
              2,
              3,
              4,
              5,
              6,
              7,
              8,
              9
            ],
            "design_motifs": [
              {
                "design_length_range": {
                  "max": 8,
                  "min": 4
                },
                "end_index": 5,
                "start_index": 0,
                "type": "replacement"
              }
            ]
          }
        },
        "modality": "peptide",
        "structure": {
          "type": "url",
          "url": "https://example.com"
        },
        "type": "structure_template",
        "rules": {
          "excluded_amino_acids": [
            "x"
          ],
          "excluded_sequence_motifs": [
            "string"
          ],
          "max_hydrophobic_fraction": 0
        }
      },
      "name": "name"
    }
  ]
}