Estimate cost for a protein design run
Estimate the cost of a protein design run without creating any resource or consuming GPU.
Body ParametersJSONExpand Collapse
binder_specification: object { chain_selection, modality, structure, 2 more } or object { entities, modality, type, 2 more } or object { binder, type, rules } or object { binder_specifications, type } Binder specification for protein design. Use no_template for sequence-defined binders, structure_template for uploaded binder structures, boltz_curated for Boltz-managed nanobody and antibody defaults, or uniformly_sampled_specifications to sample uniformly across multiple binder specifications.
Binder specification for protein design. Use no_template for sequence-defined binders, structure_template for uploaded binder structures, boltz_curated for Boltz-managed nanobody and antibody defaults, or uniformly_sampled_specifications to sample uniformly across multiple binder specifications.
StructureTemplateBinderSpec object { chain_selection, modality, structure, 2 more } Binder specification starting from an existing 3D structure. Upload a CIF/PDB file and select which chains to include, which residues to keep, and which regions to redesign. Only chains included in chain_selection are part of the pipeline run.
Binder specification starting from an existing 3D structure. Upload a CIF/PDB file and select which chains to include, which residues to keep, and which regions to redesign. Only chains included in chain_selection are part of the pipeline run.
chain_selection: map[object { chain_type, crop_residues, design_motifs } or object { chain_type } ]Chains selected from the uploaded binder structure, keyed by chain ID. Only chains listed here are included in the pipeline run — any chains omitted from this mapping are ignored. Each value defines which residues to keep (crop_residues). Omit design_motifs to include the chain as fixed scaffold context.
Chains selected from the uploaded binder structure, keyed by chain ID. Only chains listed here are included in the pipeline run — any chains omitted from this mapping are ignored. Each value defines which residues to keep (crop_residues). Omit design_motifs to include the chain as fixed scaffold context.
StructureTemplatePolymerChainSpec object { chain_type, crop_residues, design_motifs } Per-chain crop and design specification for a polymer chain in structure_template mode.
Per-chain crop and design specification for a polymer chain in structure_template mode.
crop_residues: array of number or "all"0-indexed residue indices to retain from this chain, or ‘all’ to keep all residues. Residues not listed are removed before design.
0-indexed residue indices to retain from this chain, or ‘all’ to keep all residues. Residues not listed are removed before design.
design_motifs: optional array of object { design_length_range, end_index, start_index, type } or object { after_residue_index, design_length_range, type } Optional motifs (replacement or insertion) defining which regions to redesign on this chain. Omit this field to include the chain as fixed scaffold context.
Optional motifs (replacement or insertion) defining which regions to redesign on this chain. Omit this field to include the chain as fixed scaffold context.
ReplacementMotif object { design_length_range, end_index, start_index, type } Replace a contiguous region of the sequence with a designed segment. Residues from start_index to end_index (inclusive) are replaced with a new sequence of the specified length.
Replace a contiguous region of the sequence with a designed segment. Residues from start_index to end_index (inclusive) are replaced with a new sequence of the specified length.
InsertionMotif object { after_residue_index, design_length_range, type } Insert a designed segment at a specific position in the sequence.
Insert a designed segment at a specific position in the sequence.
structure: object { type, url } or object { data, media_type, type } How to provide a CIF structure file. URLs are auto-detected; base64 uploads must use chemical/x-cif media type.
How to provide a CIF structure file. URLs are auto-detected; base64 uploads must use chemical/x-cif media type.
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction } Constraints applied during sequence design
Constraints applied during sequence design
Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)
NoTemplateBinderSpec object { entities, modality, type, 2 more } Binder specification without a structural template. Define the binder from sequence components (fixed and designed segments) without providing a starting 3D structure.
Binder specification without a structural template. Define the binder from sequence components (fixed and designed segments) without providing a starting 3D structure.
entities: array of object { chain_ids, type, value, 2 more } or object { chain_ids, type, value, 2 more } or object { chain_ids, type, value, 2 more } or 4 moreBinder entities composing the design. At least one must be a designed_protein entity. Additional fixed entities (RNA, DNA, ligands) can be included as part of the complex.
Binder entities composing the design. At least one must be a designed_protein entity. Additional fixed entities (RNA, DNA, ligands) can be included as part of the complex.
DesignedProteinEntity object { chain_ids, type, value, 2 more } Protein binder entity with designed and/or fixed segments.
Protein binder entity with designed and/or fixed segments.
Binder sequence specification. Fixed amino acids are written as literal single-letter codes. Designed regions are written as a length (fixed) or a length range (min..max). Example: “MKTAYI5..10VKSHFSRQ” means fixed MKTAYI, then 5-10 designed residues, then fixed VKSHFSRQ. “20” means 20 fully designed residues. “ACDE8GHI” means fixed ACDE, then 8 designed residues, then fixed GHI.
FixedProteinEntity object { chain_ids, type, value, 2 more } A fixed protein entity whose sequence is not redesigned.
A fixed protein entity whose sequence is not redesigned.
FixedRnaEntity object { chain_ids, type, value, 2 more }
FixedDnaEntity object { chain_ids, type, value, 2 more }
GlycanEntity object { bonds, chain_ids, residues, type } Branched glycan represented as an explicit graph of CCD monosaccharide residues.
Branched glycan represented as an explicit graph of CCD monosaccharide residues.
bonds: array of object { atom1, atom2 } Covalent bonds connecting the glycan residues. A single-residue glycan uses an empty array.
Covalent bonds connecting the glycan residues. A single-residue glycan uses an empty array.
bonds: optional array of object { atom1, atom2 } Covalent bond constraints between atoms in the binder complex. If defining bonds where an atom is part of a designed protein chain, assume residue indices count designed regions as the minimum length. Example: designed protein “1..3C1..2”, “C” is residue 1 (0-indexed) of the designed protein.
Covalent bond constraints between atoms in the binder complex. If defining bonds where an atom is part of a designed protein chain, assume residue indices count designed regions as the minimum length. Example: designed protein “1..3C1..2”, “C” is residue 1 (0-indexed) of the designed protein.
atom1: object { atom_name, chain_id, residue_index, type } or object { atom_id, chain_id, residue_id, type } or object { atom_map, chain_id, type } or object { atom_name, chain_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
CcdAtom object { atom_id, chain_id, residue_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
SmilesAtom object { atom_map, chain_id, type } Atom reference using an explicit numeric atom-map in the input SMILES.
Atom reference using an explicit numeric atom-map in the input SMILES.
LigandAtom object { atom_name, chain_id, type } Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
atom2: object { atom_name, chain_id, residue_index, type } or object { atom_id, chain_id, residue_id, type } or object { atom_map, chain_id, type } or object { atom_name, chain_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
CcdAtom object { atom_id, chain_id, residue_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
SmilesAtom object { atom_map, chain_id, type } Atom reference using an explicit numeric atom-map in the input SMILES.
Atom reference using an explicit numeric atom-map in the input SMILES.
LigandAtom object { atom_name, chain_id, type } Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction } Constraints applied during sequence design
Constraints applied during sequence design
Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)
BoltzCuratedBinderSpec object { binder, type, rules } Boltz-managed curated binder specification. Choose a curated nanobody or antibody family and Boltz will select from maintained template lists during design. The curated lists are managed by Boltz and may be updated over time to improve quality and coverage.
Boltz-managed curated binder specification. Choose a curated nanobody or antibody family and Boltz will select from maintained template lists during design. The curated lists are managed by Boltz and may be updated over time to improve quality and coverage.
binder: "boltz_nanobody" or "boltz_antibody"Boltz-managed curated binder family. Boltz maintains and may update the underlying template lists on behalf of customers.
Boltz-managed curated binder family. Boltz maintains and may update the underlying template lists on behalf of customers.
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction } Constraints applied during sequence design
Constraints applied during sequence design
Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)
UniformlySampledBinderSpec object { binder_specifications, type } A collection of binder specifications sampled uniformly during protein design. This lets one run explore multiple binder definitions while keeping each generation request shape unchanged.
A collection of binder specifications sampled uniformly during protein design. This lets one run explore multiple binder definitions while keeping each generation request shape unchanged.
binder_specifications: array of object { chain_selection, modality, structure, 2 more } or object { entities, modality, type, 2 more } or object { binder, type, rules } Binder specifications to sample uniformly when generating designs. Each generation samples one specification from this list; over larger runs this gives roughly equal representation.
Binder specifications to sample uniformly when generating designs. Each generation samples one specification from this list; over larger runs this gives roughly equal representation.
StructureTemplateBinderSpec object { chain_selection, modality, structure, 2 more } Binder specification starting from an existing 3D structure. Upload a CIF/PDB file and select which chains to include, which residues to keep, and which regions to redesign. Only chains included in chain_selection are part of the pipeline run.
Binder specification starting from an existing 3D structure. Upload a CIF/PDB file and select which chains to include, which residues to keep, and which regions to redesign. Only chains included in chain_selection are part of the pipeline run.
chain_selection: map[object { chain_type, crop_residues, design_motifs } or object { chain_type } ]Chains selected from the uploaded binder structure, keyed by chain ID. Only chains listed here are included in the pipeline run — any chains omitted from this mapping are ignored. Each value defines which residues to keep (crop_residues). Omit design_motifs to include the chain as fixed scaffold context.
Chains selected from the uploaded binder structure, keyed by chain ID. Only chains listed here are included in the pipeline run — any chains omitted from this mapping are ignored. Each value defines which residues to keep (crop_residues). Omit design_motifs to include the chain as fixed scaffold context.
StructureTemplatePolymerChainSpec object { chain_type, crop_residues, design_motifs } Per-chain crop and design specification for a polymer chain in structure_template mode.
Per-chain crop and design specification for a polymer chain in structure_template mode.
crop_residues: array of number or "all"0-indexed residue indices to retain from this chain, or ‘all’ to keep all residues. Residues not listed are removed before design.
0-indexed residue indices to retain from this chain, or ‘all’ to keep all residues. Residues not listed are removed before design.
design_motifs: optional array of object { design_length_range, end_index, start_index, type } or object { after_residue_index, design_length_range, type } Optional motifs (replacement or insertion) defining which regions to redesign on this chain. Omit this field to include the chain as fixed scaffold context.
Optional motifs (replacement or insertion) defining which regions to redesign on this chain. Omit this field to include the chain as fixed scaffold context.
ReplacementMotif object { design_length_range, end_index, start_index, type } Replace a contiguous region of the sequence with a designed segment. Residues from start_index to end_index (inclusive) are replaced with a new sequence of the specified length.
Replace a contiguous region of the sequence with a designed segment. Residues from start_index to end_index (inclusive) are replaced with a new sequence of the specified length.
InsertionMotif object { after_residue_index, design_length_range, type } Insert a designed segment at a specific position in the sequence.
Insert a designed segment at a specific position in the sequence.
structure: object { type, url } or object { data, media_type, type } How to provide a CIF structure file. URLs are auto-detected; base64 uploads must use chemical/x-cif media type.
How to provide a CIF structure file. URLs are auto-detected; base64 uploads must use chemical/x-cif media type.
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction } Constraints applied during sequence design
Constraints applied during sequence design
Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)
NoTemplateBinderSpec object { entities, modality, type, 2 more } Binder specification without a structural template. Define the binder from sequence components (fixed and designed segments) without providing a starting 3D structure.
Binder specification without a structural template. Define the binder from sequence components (fixed and designed segments) without providing a starting 3D structure.
entities: array of object { chain_ids, type, value, 2 more } or object { chain_ids, type, value, 2 more } or object { chain_ids, type, value, 2 more } or 4 moreBinder entities composing the design. At least one must be a designed_protein entity. Additional fixed entities (RNA, DNA, ligands) can be included as part of the complex.
Binder entities composing the design. At least one must be a designed_protein entity. Additional fixed entities (RNA, DNA, ligands) can be included as part of the complex.
DesignedProteinEntity object { chain_ids, type, value, 2 more } Protein binder entity with designed and/or fixed segments.
Protein binder entity with designed and/or fixed segments.
Binder sequence specification. Fixed amino acids are written as literal single-letter codes. Designed regions are written as a length (fixed) or a length range (min..max). Example: “MKTAYI5..10VKSHFSRQ” means fixed MKTAYI, then 5-10 designed residues, then fixed VKSHFSRQ. “20” means 20 fully designed residues. “ACDE8GHI” means fixed ACDE, then 8 designed residues, then fixed GHI.
FixedProteinEntity object { chain_ids, type, value, 2 more } A fixed protein entity whose sequence is not redesigned.
A fixed protein entity whose sequence is not redesigned.
FixedRnaEntity object { chain_ids, type, value, 2 more }
FixedDnaEntity object { chain_ids, type, value, 2 more }
GlycanEntity object { bonds, chain_ids, residues, type } Branched glycan represented as an explicit graph of CCD monosaccharide residues.
Branched glycan represented as an explicit graph of CCD monosaccharide residues.
bonds: array of object { atom1, atom2 } Covalent bonds connecting the glycan residues. A single-residue glycan uses an empty array.
Covalent bonds connecting the glycan residues. A single-residue glycan uses an empty array.
bonds: optional array of object { atom1, atom2 } Covalent bond constraints between atoms in the binder complex. If defining bonds where an atom is part of a designed protein chain, assume residue indices count designed regions as the minimum length. Example: designed protein “1..3C1..2”, “C” is residue 1 (0-indexed) of the designed protein.
Covalent bond constraints between atoms in the binder complex. If defining bonds where an atom is part of a designed protein chain, assume residue indices count designed regions as the minimum length. Example: designed protein “1..3C1..2”, “C” is residue 1 (0-indexed) of the designed protein.
atom1: object { atom_name, chain_id, residue_index, type } or object { atom_id, chain_id, residue_id, type } or object { atom_map, chain_id, type } or object { atom_name, chain_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
CcdAtom object { atom_id, chain_id, residue_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
SmilesAtom object { atom_map, chain_id, type } Atom reference using an explicit numeric atom-map in the input SMILES.
Atom reference using an explicit numeric atom-map in the input SMILES.
LigandAtom object { atom_name, chain_id, type } Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
atom2: object { atom_name, chain_id, residue_index, type } or object { atom_id, chain_id, residue_id, type } or object { atom_map, chain_id, type } or object { atom_name, chain_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
CcdAtom object { atom_id, chain_id, residue_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
SmilesAtom object { atom_map, chain_id, type } Atom reference using an explicit numeric atom-map in the input SMILES.
Atom reference using an explicit numeric atom-map in the input SMILES.
LigandAtom object { atom_name, chain_id, type } Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction } Constraints applied during sequence design
Constraints applied during sequence design
Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)
BoltzCuratedBinderSpec object { binder, type, rules } Boltz-managed curated binder specification. Choose a curated nanobody or antibody family and Boltz will select from maintained template lists during design. The curated lists are managed by Boltz and may be updated over time to improve quality and coverage.
Boltz-managed curated binder specification. Choose a curated nanobody or antibody family and Boltz will select from maintained template lists during design. The curated lists are managed by Boltz and may be updated over time to improve quality and coverage.
binder: "boltz_nanobody" or "boltz_antibody"Boltz-managed curated binder family. Boltz maintains and may update the underlying template lists on behalf of customers.
Boltz-managed curated binder family. Boltz maintains and may update the underlying template lists on behalf of customers.
rules: optional object { excluded_amino_acids, excluded_sequence_motifs, max_hydrophobic_fraction } Constraints applied during sequence design
Constraints applied during sequence design
Single-letter amino acid codes to exclude from design (e.g. [‘C’, ‘P’] to exclude cysteine and proline)
Number of protein designs to generate. Must be between 10 and 1,000,000.
target: object { chain_selection, structure, type } or object { entities, type, bonds, 4 more } Target specification (structure template or template-free)
Target specification (structure template or template-free)
StructureTemplateTarget object { chain_selection, structure, type } Target defined by an uploaded 3D structure (CIF or PDB file). Only chains included in chain_selection are used.
Target defined by an uploaded 3D structure (CIF or PDB file). Only chains included in chain_selection are used.
chain_selection: map[object { chain_type, crop_residues, epitope_residues, 2 more } or object { chain_type } ]Chains selected from the uploaded structure, keyed by chain ID. Only chains listed here are included in the pipeline run — any chains omitted from this mapping are ignored. Each value defines which residues to keep, which are epitope residues, which are non-binding residues, and which are flexible.
Chains selected from the uploaded structure, keyed by chain ID. Only chains listed here are included in the pipeline run — any chains omitted from this mapping are ignored. Each value defines which residues to keep, which are epitope residues, which are non-binding residues, and which are flexible.
StructureTemplateTargetPolymerChainSpec object { chain_type, crop_residues, epitope_residues, 2 more } Per-chain specification for a polymer (protein/RNA/DNA) chain in a structure template target.
Per-chain specification for a polymer (protein/RNA/DNA) chain in a structure template target.
crop_residues: array of number or "all"0-indexed residue indices to retain from this chain, or ‘all’ to keep all residues. Residues not listed are excluded from the pipeline run.
0-indexed residue indices to retain from this chain, or ‘all’ to keep all residues. Residues not listed are excluded from the pipeline run.
0-indexed residue indices where binder contact is desired (the epitope). All indices must be present in crop_residues and must not overlap non_binding_residues.
NoTemplateTarget object { entities, type, bonds, 4 more } Target defined by sequences only, without a 3D structure template
Target defined by sequences only, without a 3D structure template
entities: array of object { chain_ids, type, value, 2 more } or object { chain_ids, type, value, 2 more } or object { chain_ids, type, value, 2 more } or 3 moreEntities (proteins, RNA, DNA, ligands) defining the target complex.
Entities (proteins, RNA, DNA, ligands) defining the target complex.
ProteinEntity object { chain_ids, type, value, 2 more }
RnaEntity object { chain_ids, type, value, 2 more }
DnaEntity object { chain_ids, type, value, 2 more }
GlycanEntity object { bonds, chain_ids, residues, type } Branched glycan represented as an explicit graph of CCD monosaccharide residues.
Branched glycan represented as an explicit graph of CCD monosaccharide residues.
bonds: array of object { atom1, atom2 } Covalent bonds connecting the glycan residues. A single-residue glycan uses an empty array.
Covalent bonds connecting the glycan residues. A single-residue glycan uses an empty array.
bonds: optional array of object { atom1, atom2 } Covalent bond constraints between atoms in the target complex. Ligand atom references support CCD atom names and explicitly atom-mapped SMILES atoms.
Covalent bond constraints between atoms in the target complex. Ligand atom references support CCD atom names and explicitly atom-mapped SMILES atoms.
atom1: object { atom_name, chain_id, residue_index, type } or object { atom_id, chain_id, residue_id, type } or object { atom_map, chain_id, type } or object { atom_name, chain_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
CcdAtom object { atom_id, chain_id, residue_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
SmilesAtom object { atom_map, chain_id, type } Atom reference using an explicit numeric atom-map in the input SMILES.
Atom reference using an explicit numeric atom-map in the input SMILES.
LigandAtom object { atom_name, chain_id, type } Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
atom2: object { atom_name, chain_id, residue_index, type } or object { atom_id, chain_id, residue_id, type } or object { atom_map, chain_id, type } or object { atom_name, chain_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
CcdAtom object { atom_id, chain_id, residue_id, type } Atom reference for a specific CCD residue in a glycan graph.
Atom reference for a specific CCD residue in a glycan graph.
SmilesAtom object { atom_map, chain_id, type } Atom reference using an explicit numeric atom-map in the input SMILES.
Atom reference using an explicit numeric atom-map in the input SMILES.
LigandAtom object { atom_name, chain_id, type } Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
Atom reference for a single-residue ligand_ccd or an explicitly atom-mapped SMILES ligand. Glycan bonds use ccd_atom; new SMILES bonds should use smiles_atom.
constraints: optional array of object { binder_chain_id, contact_residues, max_distance_angstrom, 2 more } or object { max_distance_angstrom, token1, token2, 2 more } Structural constraints (pocket and contact). Ligand atom references support CCD atom names and explicitly atom-mapped SMILES atoms.
Structural constraints (pocket and contact). Ligand atom references support CCD atom names and explicitly atom-mapped SMILES atoms.
PocketConstraint object { binder_chain_id, contact_residues, max_distance_angstrom, 2 more } Constrains the binder to interact with specific pocket residues on the target.
Constrains the binder to interact with specific pocket residues on the target.
Binding pocket residues keyed by chain ID. Each key is a chain ID (e.g. “A”) and the value is an array of 0-indexed residue indices that define the pocket on that chain.
ContactConstraint object { max_distance_angstrom, token1, token2, 2 more } Maximum-distance contact constraint between two polymer residues or ligand atoms.
Maximum-distance contact constraint between two polymer residues or ligand atoms.
token1: object { chain_id, residue_index, type } or object { atom_name, chain_id, type } Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom.
Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom.
LigandContactToken object { atom_name, chain_id, type } Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom.
Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom.
token2: object { chain_id, residue_index, type } or object { atom_name, chain_id, type } Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom.
Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom.
LigandContactToken object { atom_name, chain_id, type } Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom.
Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom.
Chain IDs of ligand entities that are part of the binding epitope. Ligands are marked as epitope in full (no residue-level selection).
ReturnsExpand Collapse
breakdown: object { application, cost_per_unit_usd, num_units } Cost breakdown for the billed application.
Cost breakdown for the billed application.
application: "structure_and_binding" or "small_molecule_design" or "small_molecule_library_screen" or 4 more
Estimate cost for a protein design run
curl https://api.boltz.bio/compute/v1/protein/design/estimate-cost \
-H 'Content-Type: application/json' \
-H "x-api-key: $BOLTZ_API_KEY" \
-d '{
"binder_specification": {
"chain_selection": {
"B": {
"chain_type": "polymer",
"crop_residues": [
0,
1,
2,
3,
4,
5,
6,
7,
8,
9
],
"design_motifs": [
{
"design_length_range": {
"max": 8,
"min": 4
},
"end_index": 5,
"start_index": 0,
"type": "replacement"
}
]
}
},
"modality": "peptide",
"structure": {
"type": "url",
"url": "https://example.com"
},
"type": "structure_template"
},
"num_proteins": 10,
"target": {
"chain_selection": {
"A": {
"chain_type": "polymer",
"crop_residues": [
0,
1,
2,
3,
4,
5,
6,
7,
8,
9,
10,
11,
12
],
"epitope_residues": [
10,
11,
12
],
"flexible_residues": [
5,
6,
7
],
"non_binding_residues": [
0,
1,
2
]
}
},
"structure": {
"type": "url",
"url": "https://example.com"
},
"type": "structure_template"
}
}'{
"breakdown": {
"application": "structure_and_binding",
"cost_per_unit_usd": "0.0500",
"num_units": 1
},
"disclaimer": "This is an estimate only and may differ from your actual charges. Final billing is based on exact token counts computed at run time. For large library screens, the estimate is extrapolated from a sample and may be less accurate for highly variable inputs.",
"estimated_cost_usd": "0.0500"
}Returns Examples
{
"breakdown": {
"application": "structure_and_binding",
"cost_per_unit_usd": "0.0500",
"num_units": 1
},
"disclaimer": "This is an estimate only and may differ from your actual charges. Final billing is based on exact token counts computed at run time. For large library screens, the estimate is extrapolated from a sample and may be less accurate for highly variable inputs.",
"estimated_cost_usd": "0.0500"
}