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Protein

Protein Engine — design novel protein binders and screen protein libraries against targets. Includes de novo protein design and library screening.

ProteinDesign

Generate novel protein binders optimized for binding to a target structure. Binder specifications can be provided directly, uploaded as structure templates, or selected from Boltz-managed curated nanobody and antibody defaults. Results are scored by binding confidence (likelihood of protein-protein interaction) and structure confidence.

Start a protein de novo design run
POST/compute/v1/protein/design
List protein design runs
GET/compute/v1/protein/design
Get protein design run status
GET/compute/v1/protein/design/{id}
Get generated protein designs
GET/compute/v1/protein/design/{id}/results
Stop a running protein design run
POST/compute/v1/protein/design/{id}/stop
Delete protein design run data
POST/compute/v1/protein/design/{id}/delete-data
Estimate cost for a protein design run
POST/compute/v1/protein/design/estimate-cost

ProteinLibrary Screen

Screen an existing library of proteins against a target structure. Results are scored by binding confidence (likelihood of protein-protein interaction) and structure confidence.

Start a protein library screen
POST/compute/v1/protein/library-screen
List protein library screens
GET/compute/v1/protein/library-screen
Get protein library screen status
GET/compute/v1/protein/library-screen/{id}
Get screened protein candidates
GET/compute/v1/protein/library-screen/{id}/results
Stop a running protein library screen
POST/compute/v1/protein/library-screen/{id}/stop
Delete protein library screen data
POST/compute/v1/protein/library-screen/{id}/delete-data
Estimate cost for a protein library screen
POST/compute/v1/protein/library-screen/estimate-cost