## Resume a stopped protein design run `client.Protein.Design.Resume(ctx, id) (*ProteinDesignResumeResponse, error)` **post** `/compute/v1/protein/design/{id}/resume` Resume a stopped protein design run from its last checkpoint ### Parameters - `id string` ### Returns - `type ProteinDesignResumeResponse struct{…}` A protein design pipeline run that generates novel protein binders - `ID string` Unique ProteinDesignRun identifier - `CompletedAt Time` - `CreatedAt Time` - `DataDeletedAt Time` When the input, output, and result data was permanently deleted. Null if data has not been deleted. - `Engine Boltzprot` Deprecated. Use pipeline instead. - `const BoltzprotBoltzprot Boltzprot = "boltzprot"` - `EngineVersion String1_0` Deprecated. Use pipeline_version instead. - `const String1_01_0 String1_0 = "1.0"` - `Error ProteinDesignResumeResponseError` - `Code string` Machine-readable error code - `Message string` Human-readable error message - `Details any` Additional field-level error details keyed by input path, when available. - `Input ProteinDesignResumeResponseInput` Pipeline input (null if data deleted) - `BinderSpecification ProteinDesignResumeResponseInputBinderSpecificationUnion` Binder specification for protein design. Use no_template for sequence-defined binders, structure_template for uploaded binder structures, boltz_curated for Boltz-managed nanobody and antibody defaults, or uniformly_sampled_specifications to sample uniformly across multiple binder specifications. - `type ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponse struct{…}` Binder specification starting from an existing 3D structure. Upload a CIF/PDB file and select which chains to include, which residues to keep, and which regions to redesign. Only chains included in chain_selection are part of the pipeline run. - `ChainSelection map[string, ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionUnion]` Chains selected from the uploaded binder structure, keyed by chain ID. Only chains listed here are included in the pipeline run — any chains omitted from this mapping are ignored. Each value defines which residues to keep (crop_residues). Omit design_motifs to include the chain as fixed scaffold context. - `type ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpec struct{…}` Per-chain crop and design specification for a polymer chain in structure_template mode. - `ChainType Polymer` - `const PolymerPolymer Polymer = "polymer"` - `CropResidues ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecCropResiduesUnion` 0-indexed residue indices to retain from this chain, or 'all' to keep all residues. Residues not listed are removed before design. - `type ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecCropResiduesArray []int64` - `type All string` - `const AllAll All = "all"` - `DesignMotifs []ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecDesignMotifUnion` Optional motifs (replacement or insertion) defining which regions to redesign on this chain. Omit this field to include the chain as fixed scaffold context. - `type ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecDesignMotifReplacementMotif struct{…}` Replace a contiguous region of the sequence with a designed segment. Residues from start_index to end_index (inclusive) are replaced with a new sequence of the specified length. - `DesignLengthRange ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecDesignMotifReplacementMotifDesignLengthRange` Allowed sequence length range for designed regions - `Max int64` Maximum sequence length in residues. Must be >= min. - `Min int64` Minimum sequence length in residues - `EndIndex int64` 0-indexed end residue (inclusive) - `StartIndex int64` 0-indexed start residue (inclusive) - `Type Replacement` - `const ReplacementReplacement Replacement = "replacement"` - `type ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecDesignMotifInsertionMotif struct{…}` Insert a designed segment at a specific position in the sequence. - `AfterResidueIndex int64` 0-indexed position after which to insert. Use -1 to insert before the first residue. - `DesignLengthRange ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecDesignMotifInsertionMotifDesignLengthRange` Allowed sequence length range for designed regions - `Max int64` Maximum sequence length in residues. Must be >= min. - `Min int64` Minimum sequence length in residues - `Type Insertion` - `const InsertionInsertion Insertion = "insertion"` - `type ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplateLigandChainSpec struct{…}` Per-chain specification for a ligand chain in structure_template mode. The full ligand is always included. - `ChainType Ligand` - `const LigandLigand Ligand = "ligand"` - `Modality ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseModality` - `const ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseModalityPeptide ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseModality = "peptide"` - `const ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseModalityAntibody ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseModality = "antibody"` - `const ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseModalityNanobody ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseModality = "nanobody"` - `const ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseModalityCustomProtein ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseModality = "custom_protein"` - `Structure ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseStructure` - `URL string` URL to download the file - `URLExpiresAt Time` When the presigned URL expires - `Type StructureTemplate` - `const StructureTemplateStructureTemplate StructureTemplate = "structure_template"` - `Rules ProteinDesignResumeResponseInputBinderSpecificationStructureTemplateBinderSpecResponseRules` Constraints applied during sequence design - `ExcludedAminoAcids []string` Single-letter amino acid codes to exclude from design (e.g. ['C', 'P'] to exclude cysteine and proline) - `ExcludedSequenceMotifs []string` Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. "NGS", "NXS"). - `MaxHydrophobicFraction float64` Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable. - `type ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponse struct{…}` Binder specification without a structural template. Define the binder from sequence components (fixed and designed segments) without providing a starting 3D structure. - `Entities []ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseEntityUnion` Binder entities composing the design. At least one must be a designed_protein entity. Additional fixed entities (RNA, DNA, ligands) can be included as part of the complex. - `type ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseEntityDesignedProteinEntityResponse struct{…}` Protein binder entity with designed and/or fixed segments. - `ChainIDs []string` Chain IDs to assign to this entity - `Type DesignedProtein` - `const DesignedProteinDesignedProtein DesignedProtein = "designed_protein"` - `Value string` Binder sequence specification. Fixed amino acids are written as literal single-letter codes. Designed regions are written as a length (fixed) or a length range (min..max). Example: "MKTAYI5..10VKSHFSRQ" means fixed MKTAYI, then 5-10 designed residues, then fixed VKSHFSRQ. "20" means 20 fully designed residues. "ACDE8GHI" means fixed ACDE, then 8 designed residues, then fixed GHI. - `Cyclic bool` Whether the sequence is cyclic - `Modifications []ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseEntityDesignedProteinEntityResponseModification` Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported. - `ResidueIndex int64` 0-based index of the residue to modify - `Type Ccd` Modification format. Only CCD polymer modifications are supported. - `const CcdCcd Ccd = "ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'MSE' for selenomethionine, 'SEP' for phosphoserine) - `type ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseEntityFixedProteinEntityResponse struct{…}` A fixed protein entity whose sequence is not redesigned. - `ChainIDs []string` Chain IDs to assign to this entity - `Type Protein` - `const ProteinProtein Protein = "protein"` - `Value string` Amino acid sequence (one-letter codes) - `Cyclic bool` Whether the sequence is cyclic - `Modifications []ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseEntityFixedProteinEntityResponseModification` Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported. - `ResidueIndex int64` 0-based index of the residue to modify - `Type Ccd` Modification format. Only CCD polymer modifications are supported. - `const CcdCcd Ccd = "ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'MSE' for selenomethionine, 'SEP' for phosphoserine) - `type ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseEntityFixedRnaEntityResponse struct{…}` - `ChainIDs []string` Chain IDs to assign to this entity - `Type Rna` - `const RnaRna Rna = "rna"` - `Value string` RNA nucleotide sequence (A, C, G, U, N) - `Cyclic bool` Whether the sequence is cyclic - `Modifications []ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseEntityFixedRnaEntityResponseModification` Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported. - `ResidueIndex int64` 0-based index of the residue to modify - `Type Ccd` Modification format. Only CCD polymer modifications are supported. - `const CcdCcd Ccd = "ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'MSE' for selenomethionine, 'SEP' for phosphoserine) - `type ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseEntityFixedDnaEntityResponse struct{…}` - `ChainIDs []string` Chain IDs to assign to this entity - `Type Dna` - `const DnaDna Dna = "dna"` - `Value string` DNA nucleotide sequence (A, C, G, T, N) - `Cyclic bool` Whether the sequence is cyclic - `Modifications []ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseEntityFixedDnaEntityResponseModification` Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported. - `ResidueIndex int64` 0-based index of the residue to modify - `Type Ccd` Modification format. Only CCD polymer modifications are supported. - `const CcdCcd Ccd = "ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'MSE' for selenomethionine, 'SEP' for phosphoserine) - `type ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseEntityFixedLigandSmilesEntityResponse struct{…}` - `ChainIDs []string` Chain IDs to assign to this entity - `Type LigandSmiles` - `const LigandSmilesLigandSmiles LigandSmiles = "ligand_smiles"` - `Value string` SMILES string representing the ligand - `type ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseEntityFixedLigandCcdEntityResponse struct{…}` - `ChainIDs []string` Chain IDs to assign to this entity - `Type LigandCcd` - `const LigandCcdLigandCcd LigandCcd = "ligand_ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'ATP', 'ADP') - `Modality ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseModality` - `const ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseModalityPeptide ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseModality = "peptide"` - `const ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseModalityAntibody ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseModality = "antibody"` - `const ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseModalityNanobody ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseModality = "nanobody"` - `const ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseModalityCustomProtein ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseModality = "custom_protein"` - `Type NoTemplate` - `const NoTemplateNoTemplate NoTemplate = "no_template"` - `Bonds []ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseBond` Covalent bond constraints between atoms in the binder complex. If defining bonds where an atom is part of a designed protein chain, assume residue indices count designed regions as the minimum length. Example: designed protein "1..3C1..2", "C" is residue 1 (0-indexed) of the designed protein. - `Atom1 ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseBondAtom1Union` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `type ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseBondAtom1LigandAtomResponse struct{…}` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `AtomName string` Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters. - `ChainID string` Chain ID containing the atom - `Type LigandAtom` - `const LigandAtomLigandAtom LigandAtom = "ligand_atom"` - `type ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseBondAtom1PolymerAtomResponse struct{…}` - `AtomName string` Standardized atom name (verifiable in CIF file on RCSB) - `ChainID string` Chain ID containing the atom - `ResidueIndex int64` 0-based residue index - `Type PolymerAtom` - `const PolymerAtomPolymerAtom PolymerAtom = "polymer_atom"` - `Atom2 ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseBondAtom2Union` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `type ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseBondAtom2LigandAtomResponse struct{…}` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `AtomName string` Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters. - `ChainID string` Chain ID containing the atom - `Type LigandAtom` - `const LigandAtomLigandAtom LigandAtom = "ligand_atom"` - `type ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseBondAtom2PolymerAtomResponse struct{…}` - `AtomName string` Standardized atom name (verifiable in CIF file on RCSB) - `ChainID string` Chain ID containing the atom - `ResidueIndex int64` 0-based residue index - `Type PolymerAtom` - `const PolymerAtomPolymerAtom PolymerAtom = "polymer_atom"` - `Rules ProteinDesignResumeResponseInputBinderSpecificationNoTemplateBinderSpecResponseRules` Constraints applied during sequence design - `ExcludedAminoAcids []string` Single-letter amino acid codes to exclude from design (e.g. ['C', 'P'] to exclude cysteine and proline) - `ExcludedSequenceMotifs []string` Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. "NGS", "NXS"). - `MaxHydrophobicFraction float64` Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable. - `type ProteinDesignResumeResponseInputBinderSpecificationBoltzCuratedBinderSpecResponse struct{…}` Boltz-managed curated binder specification. Choose a curated nanobody or antibody family and Boltz will select from maintained template lists during design. The curated lists are managed by Boltz and may be updated over time to improve quality and coverage. - `Binder ProteinDesignResumeResponseInputBinderSpecificationBoltzCuratedBinderSpecResponseBinder` Boltz-managed curated binder family. Boltz maintains and may update the underlying template lists on behalf of customers. - `const ProteinDesignResumeResponseInputBinderSpecificationBoltzCuratedBinderSpecResponseBinderBoltzNanobody ProteinDesignResumeResponseInputBinderSpecificationBoltzCuratedBinderSpecResponseBinder = "boltz_nanobody"` - `const ProteinDesignResumeResponseInputBinderSpecificationBoltzCuratedBinderSpecResponseBinderBoltzAntibody ProteinDesignResumeResponseInputBinderSpecificationBoltzCuratedBinderSpecResponseBinder = "boltz_antibody"` - `Type BoltzCurated` - `const BoltzCuratedBoltzCurated BoltzCurated = "boltz_curated"` - `Rules ProteinDesignResumeResponseInputBinderSpecificationBoltzCuratedBinderSpecResponseRules` Constraints applied during sequence design - `ExcludedAminoAcids []string` Single-letter amino acid codes to exclude from design (e.g. ['C', 'P'] to exclude cysteine and proline) - `ExcludedSequenceMotifs []string` Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. "NGS", "NXS"). - `MaxHydrophobicFraction float64` Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable. - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponse struct{…}` A collection of binder specifications sampled uniformly during protein design. This lets one run explore multiple binder definitions while keeping each generation request shape unchanged. - `BinderSpecifications []ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationUnion` Binder specifications to sample uniformly when generating designs. Each generation samples one specification from this list; over larger runs this gives roughly equal representation. - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponse struct{…}` Binder specification starting from an existing 3D structure. Upload a CIF/PDB file and select which chains to include, which residues to keep, and which regions to redesign. Only chains included in chain_selection are part of the pipeline run. - `ChainSelection map[string, ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionUnion]` Chains selected from the uploaded binder structure, keyed by chain ID. Only chains listed here are included in the pipeline run — any chains omitted from this mapping are ignored. Each value defines which residues to keep (crop_residues). Omit design_motifs to include the chain as fixed scaffold context. - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpec struct{…}` Per-chain crop and design specification for a polymer chain in structure_template mode. - `ChainType Polymer` - `const PolymerPolymer Polymer = "polymer"` - `CropResidues ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecCropResiduesUnion` 0-indexed residue indices to retain from this chain, or 'all' to keep all residues. Residues not listed are removed before design. - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecCropResiduesArray []int64` - `type All string` - `const AllAll All = "all"` - `DesignMotifs []ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecDesignMotifUnion` Optional motifs (replacement or insertion) defining which regions to redesign on this chain. Omit this field to include the chain as fixed scaffold context. - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecDesignMotifReplacementMotif struct{…}` Replace a contiguous region of the sequence with a designed segment. Residues from start_index to end_index (inclusive) are replaced with a new sequence of the specified length. - `DesignLengthRange ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecDesignMotifReplacementMotifDesignLengthRange` Allowed sequence length range for designed regions - `Max int64` Maximum sequence length in residues. Must be >= min. - `Min int64` Minimum sequence length in residues - `EndIndex int64` 0-indexed end residue (inclusive) - `StartIndex int64` 0-indexed start residue (inclusive) - `Type Replacement` - `const ReplacementReplacement Replacement = "replacement"` - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecDesignMotifInsertionMotif struct{…}` Insert a designed segment at a specific position in the sequence. - `AfterResidueIndex int64` 0-indexed position after which to insert. Use -1 to insert before the first residue. - `DesignLengthRange ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplatePolymerChainSpecDesignMotifInsertionMotifDesignLengthRange` Allowed sequence length range for designed regions - `Max int64` Maximum sequence length in residues. Must be >= min. - `Min int64` Minimum sequence length in residues - `Type Insertion` - `const InsertionInsertion Insertion = "insertion"` - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseChainSelectionStructureTemplateLigandChainSpec struct{…}` Per-chain specification for a ligand chain in structure_template mode. The full ligand is always included. - `ChainType Ligand` - `const LigandLigand Ligand = "ligand"` - `Modality ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseModality` - `const ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseModalityPeptide ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseModality = "peptide"` - `const ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseModalityAntibody ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseModality = "antibody"` - `const ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseModalityNanobody ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseModality = "nanobody"` - `const ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseModalityCustomProtein ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseModality = "custom_protein"` - `Structure ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseStructure` - `URL string` URL to download the file - `URLExpiresAt Time` When the presigned URL expires - `Type StructureTemplate` - `const StructureTemplateStructureTemplate StructureTemplate = "structure_template"` - `Rules ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationStructureTemplateBinderSpecResponseRules` Constraints applied during sequence design - `ExcludedAminoAcids []string` Single-letter amino acid codes to exclude from design (e.g. ['C', 'P'] to exclude cysteine and proline) - `ExcludedSequenceMotifs []string` Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. "NGS", "NXS"). - `MaxHydrophobicFraction float64` Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable. - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponse struct{…}` Binder specification without a structural template. Define the binder from sequence components (fixed and designed segments) without providing a starting 3D structure. - `Entities []ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseEntityUnion` Binder entities composing the design. At least one must be a designed_protein entity. Additional fixed entities (RNA, DNA, ligands) can be included as part of the complex. - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseEntityDesignedProteinEntityResponse struct{…}` Protein binder entity with designed and/or fixed segments. - `ChainIDs []string` Chain IDs to assign to this entity - `Type DesignedProtein` - `const DesignedProteinDesignedProtein DesignedProtein = "designed_protein"` - `Value string` Binder sequence specification. Fixed amino acids are written as literal single-letter codes. Designed regions are written as a length (fixed) or a length range (min..max). Example: "MKTAYI5..10VKSHFSRQ" means fixed MKTAYI, then 5-10 designed residues, then fixed VKSHFSRQ. "20" means 20 fully designed residues. "ACDE8GHI" means fixed ACDE, then 8 designed residues, then fixed GHI. - `Cyclic bool` Whether the sequence is cyclic - `Modifications []ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseEntityDesignedProteinEntityResponseModification` Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported. - `ResidueIndex int64` 0-based index of the residue to modify - `Type Ccd` Modification format. Only CCD polymer modifications are supported. - `const CcdCcd Ccd = "ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'MSE' for selenomethionine, 'SEP' for phosphoserine) - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseEntityFixedProteinEntityResponse struct{…}` A fixed protein entity whose sequence is not redesigned. - `ChainIDs []string` Chain IDs to assign to this entity - `Type Protein` - `const ProteinProtein Protein = "protein"` - `Value string` Amino acid sequence (one-letter codes) - `Cyclic bool` Whether the sequence is cyclic - `Modifications []ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseEntityFixedProteinEntityResponseModification` Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported. - `ResidueIndex int64` 0-based index of the residue to modify - `Type Ccd` Modification format. Only CCD polymer modifications are supported. - `const CcdCcd Ccd = "ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'MSE' for selenomethionine, 'SEP' for phosphoserine) - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseEntityFixedRnaEntityResponse struct{…}` - `ChainIDs []string` Chain IDs to assign to this entity - `Type Rna` - `const RnaRna Rna = "rna"` - `Value string` RNA nucleotide sequence (A, C, G, U, N) - `Cyclic bool` Whether the sequence is cyclic - `Modifications []ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseEntityFixedRnaEntityResponseModification` Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported. - `ResidueIndex int64` 0-based index of the residue to modify - `Type Ccd` Modification format. Only CCD polymer modifications are supported. - `const CcdCcd Ccd = "ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'MSE' for selenomethionine, 'SEP' for phosphoserine) - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseEntityFixedDnaEntityResponse struct{…}` - `ChainIDs []string` Chain IDs to assign to this entity - `Type Dna` - `const DnaDna Dna = "dna"` - `Value string` DNA nucleotide sequence (A, C, G, T, N) - `Cyclic bool` Whether the sequence is cyclic - `Modifications []ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseEntityFixedDnaEntityResponseModification` Optional CCD polymer modifications. Defaults to [] when omitted. SMILES modifications are not supported. - `ResidueIndex int64` 0-based index of the residue to modify - `Type Ccd` Modification format. Only CCD polymer modifications are supported. - `const CcdCcd Ccd = "ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'MSE' for selenomethionine, 'SEP' for phosphoserine) - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseEntityFixedLigandSmilesEntityResponse struct{…}` - `ChainIDs []string` Chain IDs to assign to this entity - `Type LigandSmiles` - `const LigandSmilesLigandSmiles LigandSmiles = "ligand_smiles"` - `Value string` SMILES string representing the ligand - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseEntityFixedLigandCcdEntityResponse struct{…}` - `ChainIDs []string` Chain IDs to assign to this entity - `Type LigandCcd` - `const LigandCcdLigandCcd LigandCcd = "ligand_ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'ATP', 'ADP') - `Modality ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseModality` - `const ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseModalityPeptide ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseModality = "peptide"` - `const ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseModalityAntibody ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseModality = "antibody"` - `const ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseModalityNanobody ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseModality = "nanobody"` - `const ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseModalityCustomProtein ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseModality = "custom_protein"` - `Type NoTemplate` - `const NoTemplateNoTemplate NoTemplate = "no_template"` - `Bonds []ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseBond` Covalent bond constraints between atoms in the binder complex. If defining bonds where an atom is part of a designed protein chain, assume residue indices count designed regions as the minimum length. Example: designed protein "1..3C1..2", "C" is residue 1 (0-indexed) of the designed protein. - `Atom1 ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseBondAtom1Union` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseBondAtom1LigandAtomResponse struct{…}` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `AtomName string` Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters. - `ChainID string` Chain ID containing the atom - `Type LigandAtom` - `const LigandAtomLigandAtom LigandAtom = "ligand_atom"` - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseBondAtom1PolymerAtomResponse struct{…}` - `AtomName string` Standardized atom name (verifiable in CIF file on RCSB) - `ChainID string` Chain ID containing the atom - `ResidueIndex int64` 0-based residue index - `Type PolymerAtom` - `const PolymerAtomPolymerAtom PolymerAtom = "polymer_atom"` - `Atom2 ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseBondAtom2Union` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseBondAtom2LigandAtomResponse struct{…}` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `AtomName string` Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters. - `ChainID string` Chain ID containing the atom - `Type LigandAtom` - `const LigandAtomLigandAtom LigandAtom = "ligand_atom"` - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseBondAtom2PolymerAtomResponse struct{…}` - `AtomName string` Standardized atom name (verifiable in CIF file on RCSB) - `ChainID string` Chain ID containing the atom - `ResidueIndex int64` 0-based residue index - `Type PolymerAtom` - `const PolymerAtomPolymerAtom PolymerAtom = "polymer_atom"` - `Rules ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationNoTemplateBinderSpecResponseRules` Constraints applied during sequence design - `ExcludedAminoAcids []string` Single-letter amino acid codes to exclude from design (e.g. ['C', 'P'] to exclude cysteine and proline) - `ExcludedSequenceMotifs []string` Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. "NGS", "NXS"). - `MaxHydrophobicFraction float64` Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable. - `type ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationBoltzCuratedBinderSpecResponse struct{…}` Boltz-managed curated binder specification. Choose a curated nanobody or antibody family and Boltz will select from maintained template lists during design. The curated lists are managed by Boltz and may be updated over time to improve quality and coverage. - `Binder ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationBoltzCuratedBinderSpecResponseBinder` Boltz-managed curated binder family. Boltz maintains and may update the underlying template lists on behalf of customers. - `const ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationBoltzCuratedBinderSpecResponseBinderBoltzNanobody ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationBoltzCuratedBinderSpecResponseBinder = "boltz_nanobody"` - `const ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationBoltzCuratedBinderSpecResponseBinderBoltzAntibody ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationBoltzCuratedBinderSpecResponseBinder = "boltz_antibody"` - `Type BoltzCurated` - `const BoltzCuratedBoltzCurated BoltzCurated = "boltz_curated"` - `Rules ProteinDesignResumeResponseInputBinderSpecificationUniformlySampledBinderSpecResponseBinderSpecificationBoltzCuratedBinderSpecResponseRules` Constraints applied during sequence design - `ExcludedAminoAcids []string` Single-letter amino acid codes to exclude from design (e.g. ['C', 'P'] to exclude cysteine and proline) - `ExcludedSequenceMotifs []string` Sequence motifs to exclude from designed regions. Designs containing any of these motifs are filtered out before scoring. Use X as a single-residue wildcard (e.g. "NGS", "NXS"). - `MaxHydrophobicFraction float64` Maximum allowed fraction of hydrophobic residues (I, L, V, M, F, W, Y) in designed regions. Designs exceeding this threshold are filtered out before scoring. Leave empty to disable. - `Type UniformlySampledSpecifications` - `const UniformlySampledSpecificationsUniformlySampledSpecifications UniformlySampledSpecifications = "uniformly_sampled_specifications"` - `NumProteins int64` Number of protein designs to generate. Must be between 10 and 1,000,000. - `Target ProteinDesignResumeResponseInputTargetUnion` Target specification (structure template or template-free) - `type ProteinDesignResumeResponseInputTargetStructureTemplateTargetResponse struct{…}` Target defined by an uploaded 3D structure (CIF or PDB file). Only chains included in chain_selection are used. - `ChainSelection map[string, ProteinDesignResumeResponseInputTargetStructureTemplateTargetResponseChainSelectionUnion]` Chains selected from the uploaded structure, keyed by chain ID. Only chains listed here are included in the pipeline run — any chains omitted from this mapping are ignored. Each value defines which residues to keep, which are epitope residues, which are non-binding residues, and which are flexible. - `type ProteinDesignResumeResponseInputTargetStructureTemplateTargetResponseChainSelectionStructureTemplateTargetPolymerChainSpec struct{…}` Per-chain specification for a polymer (protein/RNA/DNA) chain in a structure template target. - `ChainType Polymer` - `const PolymerPolymer Polymer = "polymer"` - `CropResidues ProteinDesignResumeResponseInputTargetStructureTemplateTargetResponseChainSelectionStructureTemplateTargetPolymerChainSpecCropResiduesUnion` 0-indexed residue indices to retain from this chain, or 'all' to keep all residues. Residues not listed are excluded from the pipeline run. - `type ProteinDesignResumeResponseInputTargetStructureTemplateTargetResponseChainSelectionStructureTemplateTargetPolymerChainSpecCropResiduesArray []int64` 0-indexed residue indices to keep - `type All string` - `const AllAll All = "all"` - `EpitopeResidues []int64` 0-indexed residue indices where binder contact is desired (the epitope). All indices must be present in crop_residues and must not overlap non_binding_residues. - `FlexibleResidues []int64` 0-indexed residue indices allowed to move during design (e.g. flexible loop regions). All indices must be present in crop_residues. - `NonBindingResidues []int64` 0-indexed residue indices where binder contact should be discouraged. All indices must be present in crop_residues and must not overlap epitope_residues. - `type ProteinDesignResumeResponseInputTargetStructureTemplateTargetResponseChainSelectionStructureTemplateTargetLigandChainSpec struct{…}` Per-chain specification for a ligand chain in a structure template target. The full ligand is always included. - `ChainType Ligand` - `const LigandLigand Ligand = "ligand"` - `Structure ProteinDesignResumeResponseInputTargetStructureTemplateTargetResponseStructure` - `URL string` URL to download the file - `URLExpiresAt Time` When the presigned URL expires - `Type StructureTemplate` - `const StructureTemplateStructureTemplate StructureTemplate = "structure_template"` - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponse struct{…}` Target defined by sequences only, without a 3D structure template - `Entities []ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseEntityUnion` Entities (proteins, RNA, DNA, ligands) defining the target complex. - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseEntityProteinEntityResponse struct{…}` - `ChainIDs []string` Chain IDs for this entity - `Type Protein` - `const ProteinProtein Protein = "protein"` - `Value string` Amino acid sequence (one-letter codes) - `Cyclic bool` Whether the sequence is cyclic - `Modifications []ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseEntityProteinEntityResponseModification` CCD post-translational modifications. Optional; defaults to an empty list when omitted. SMILES modifications are not supported. - `ResidueIndex int64` 0-based index of the residue to modify - `Type Ccd` Modification format. Only CCD polymer modifications are supported. - `const CcdCcd Ccd = "ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'MSE' for selenomethionine, 'SEP' for phosphoserine) - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseEntityRnaEntityResponse struct{…}` - `ChainIDs []string` Chain IDs for this entity - `Type Rna` - `const RnaRna Rna = "rna"` - `Value string` RNA nucleotide sequence (A, C, G, U, N) - `Cyclic bool` Whether the sequence is cyclic - `Modifications []ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseEntityRnaEntityResponseModification` CCD chemical modifications. Optional; defaults to an empty list when omitted. SMILES modifications are not supported. - `ResidueIndex int64` 0-based index of the residue to modify - `Type Ccd` Modification format. Only CCD polymer modifications are supported. - `const CcdCcd Ccd = "ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'MSE' for selenomethionine, 'SEP' for phosphoserine) - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseEntityDnaEntityResponse struct{…}` - `ChainIDs []string` Chain IDs for this entity - `Type Dna` - `const DnaDna Dna = "dna"` - `Value string` DNA nucleotide sequence (A, C, G, T, N) - `Cyclic bool` Whether the sequence is cyclic - `Modifications []ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseEntityDnaEntityResponseModification` CCD chemical modifications. Optional; defaults to an empty list when omitted. SMILES modifications are not supported. - `ResidueIndex int64` 0-based index of the residue to modify - `Type Ccd` Modification format. Only CCD polymer modifications are supported. - `const CcdCcd Ccd = "ccd"` - `Value string` CCD code from RCSB PDB (e.g. 'MSE' for selenomethionine, 'SEP' for phosphoserine) - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseEntityLigandCcdEntityResponse struct{…}` - `ChainIDs []string` Chain IDs for this ligand - `Type LigandCcd` - `const LigandCcdLigandCcd LigandCcd = "ligand_ccd"` - `Value string` CCD code (e.g., ATP, ADP) - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseEntityLigandSmilesEntityResponse struct{…}` - `ChainIDs []string` Chain IDs for this ligand - `Type LigandSmiles` - `const LigandSmilesLigandSmiles LigandSmiles = "ligand_smiles"` - `Value string` SMILES string representing the ligand - `Type NoTemplate` - `const NoTemplateNoTemplate NoTemplate = "no_template"` - `Bonds []ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseBond` Covalent bond constraints between atoms in the target complex. Ligand atom references support CCD atom names and explicitly atom-mapped SMILES atoms. - `Atom1 ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseBondAtom1Union` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseBondAtom1LigandAtomResponse struct{…}` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `AtomName string` Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters. - `ChainID string` Chain ID containing the atom - `Type LigandAtom` - `const LigandAtomLigandAtom LigandAtom = "ligand_atom"` - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseBondAtom1PolymerAtomResponse struct{…}` - `AtomName string` Standardized atom name (verifiable in CIF file on RCSB) - `ChainID string` Chain ID containing the atom - `ResidueIndex int64` 0-based residue index - `Type PolymerAtom` - `const PolymerAtomPolymerAtom PolymerAtom = "polymer_atom"` - `Atom2 ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseBondAtom2Union` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseBondAtom2LigandAtomResponse struct{…}` Ligand atom reference for a CCD atom or an explicitly atom-mapped SMILES atom. - `AtomName string` Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters. - `ChainID string` Chain ID containing the atom - `Type LigandAtom` - `const LigandAtomLigandAtom LigandAtom = "ligand_atom"` - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseBondAtom2PolymerAtomResponse struct{…}` - `AtomName string` Standardized atom name (verifiable in CIF file on RCSB) - `ChainID string` Chain ID containing the atom - `ResidueIndex int64` 0-based residue index - `Type PolymerAtom` - `const PolymerAtomPolymerAtom PolymerAtom = "polymer_atom"` - `Constraints []ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseConstraintUnion` Structural constraints (pocket and contact). Ligand atom references support CCD atom names and explicitly atom-mapped SMILES atoms. - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseConstraintPocketConstraintResponse struct{…}` Constrains the binder to interact with specific pocket residues on the target. - `BinderChainID string` Chain ID of the binder molecule - `ContactResidues map[string, []int64]` Binding pocket residues keyed by chain ID. Each key is a chain ID (e.g. "A") and the value is an array of 0-indexed residue indices that define the pocket on that chain. - `MaxDistanceAngstrom float64` Maximum allowed distance in Angstroms between binder and pocket residues. Typical range: 4-8 A. - `Type Pocket` - `const PocketPocket Pocket = "pocket"` - `Force bool` Whether to force the constraint - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseConstraintContactConstraintResponse struct{…}` Maximum-distance contact constraint between two polymer residues or ligand atoms. - `MaxDistanceAngstrom float64` Maximum distance in Angstroms - `Token1 ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseConstraintContactConstraintResponseToken1Union` Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom. - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseConstraintContactConstraintResponseToken1PolymerContactTokenResponse struct{…}` - `ChainID string` Chain ID - `ResidueIndex int64` 0-based residue index - `Type PolymerContact` - `const PolymerContactPolymerContact PolymerContact = "polymer_contact"` - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseConstraintContactConstraintResponseToken1LigandContactTokenResponse struct{…}` Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom. - `AtomName string` Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters. - `ChainID string` Chain ID - `Type LigandContact` - `const LigandContactLigandContact LigandContact = "ligand_contact"` - `Token2 ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseConstraintContactConstraintResponseToken2Union` Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom. - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseConstraintContactConstraintResponseToken2PolymerContactTokenResponse struct{…}` - `ChainID string` Chain ID - `ResidueIndex int64` 0-based residue index - `Type PolymerContact` - `const PolymerContactPolymerContact PolymerContact = "polymer_contact"` - `type ProteinDesignResumeResponseInputTargetNoTemplateTargetResponseConstraintContactConstraintResponseToken2LigandContactTokenResponse struct{…}` Ligand contact token for a CCD atom or an explicitly atom-mapped SMILES atom. - `AtomName string` Atom name. For ligand_ccd, use the standardized CIF atom name. For ligand_smiles, explicitly label the atom with numeric atom-map notation: [C:1] is referenced as C1 and [O:2] as O2. The resulting name must be unique within the molecule and at most four characters. - `ChainID string` Chain ID - `Type LigandContact` - `const LigandContactLigandContact LigandContact = "ligand_contact"` - `Type Contact` - `const ContactContact Contact = "contact"` - `Force bool` Whether to force the constraint - `EpitopeLigandChains []string` Chain IDs of ligand entities that are part of the binding epitope. Ligands are marked as epitope in full (no residue-level selection). - `EpitopeResidues map[string, []int64]` Polymer chain residues where binder contact is desired (the epitope). Each key is a chain ID of a polymer entity, each value is an array of 0-indexed residue indices. Residues must not overlap non_binding_residues on the same chain. - `NonBindingResidues map[string, []int64]` Polymer chain residues where binder contact should be discouraged. Each key is a chain ID of a polymer entity, each value is an array of 0-indexed residue indices. Residues must not overlap epitope_residues on the same chain. - `IdempotencyKey string` Client-provided key to prevent duplicate submissions on retries - `WorkspaceID string` Target workspace ID (admin keys only; ignored for workspace keys) - `Livemode bool` Whether this resource was created with a live API key. - `Pipeline Boltzprot` Pipeline used for protein design - `const BoltzprotBoltzprot Boltzprot = "boltzprot"` - `PipelineVersion String1_0` Pipeline version used for protein design - `const String1_01_0 String1_0 = "1.0"` - `Progress ProteinDesignResumeResponseProgress` - `NumProteinsGenerated int64` Number of protein binders generated so far - `TotalProteinsToGenerate int64` Total number of protein binders requested - `LatestResultID string` ID of the most recently generated result - `StartedAt Time` - `Status ProteinDesignResumeResponseStatus` - `const ProteinDesignResumeResponseStatusPending ProteinDesignResumeResponseStatus = "pending"` - `const ProteinDesignResumeResponseStatusRunning ProteinDesignResumeResponseStatus = "running"` - `const ProteinDesignResumeResponseStatusSucceeded ProteinDesignResumeResponseStatus = "succeeded"` - `const ProteinDesignResumeResponseStatusFailed ProteinDesignResumeResponseStatus = "failed"` - `const ProteinDesignResumeResponseStatusStopped ProteinDesignResumeResponseStatus = "stopped"` - `StoppedAt Time` - `WorkspaceID string` Workspace ID - `IdempotencyKey string` Client-provided idempotency key ### Example ```go package main import ( "context" "fmt" "github.com/boltz-bio/boltz-api-go" "github.com/boltz-bio/boltz-api-go/option" ) func main() { client := boltzapi.NewClient( option.WithAPIKey("My API Key"), ) response, err := client.Protein.Design.Resume(context.TODO(), "id") if err != nil { panic(err.Error()) } fmt.Printf("%+v\n", response.ID) } ``` #### Response ```json { "id": "id", "completed_at": "2019-12-27T18:11:19.117Z", "created_at": "2019-12-27T18:11:19.117Z", "data_deleted_at": "2019-12-27T18:11:19.117Z", "engine": "boltzprot", "engine_version": "1.0", "error": { "code": "code", "message": "message", "details": {} }, "input": { "binder_specification": { "chain_selection": { "B": { "chain_type": "polymer", "crop_residues": [ 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 ], "design_motifs": [ { "design_length_range": { "max": 8, "min": 4 }, "end_index": 5, "start_index": 0, "type": "replacement" } ] } }, "modality": "peptide", "structure": { "url": "https://example.com", "url_expires_at": "2019-12-27T18:11:19.117Z" }, "type": "structure_template", "rules": { "excluded_amino_acids": [ "x" ], "excluded_sequence_motifs": [ "string" ], "max_hydrophobic_fraction": 0 } }, "num_proteins": 10, "target": { "chain_selection": { "A": { "chain_type": "polymer", "crop_residues": [ 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 ], "epitope_residues": [ 10, 11, 12 ], "flexible_residues": [ 5, 6, 7 ], "non_binding_residues": [ 0, 1, 2 ] } }, "structure": { "url": "https://example.com", "url_expires_at": "2019-12-27T18:11:19.117Z" }, "type": "structure_template" }, "idempotency_key": "idempotency_key", "workspace_id": "workspace_id" }, "livemode": true, "pipeline": "boltzprot", "pipeline_version": "1.0", "progress": { "num_proteins_generated": 0, "total_proteins_to_generate": 1, "latest_result_id": "latest_result_id" }, "started_at": "2019-12-27T18:11:19.117Z", "status": "pending", "stopped_at": "2019-12-27T18:11:19.117Z", "workspace_id": "workspace_id", "idempotency_key": "idempotency_key" } ```