Protein

Protein Engine — design novel protein binders and screen protein libraries against targets. Includes de novo protein design and library screening.

ProteinDesign

Generate novel protein binders optimized for binding to a target structure. Binder specifications can be provided directly, uploaded as structure templates, or selected from Boltz-managed curated nanobody and antibody defaults. Results are scored by binding confidence (likelihood of protein-protein interaction) and structure confidence.

Start a protein de novo design run

$ boltz-api protein:design start

POST/compute/v1/protein/design

List protein design runs

$ boltz-api protein:design list

GET/compute/v1/protein/design

Get protein design run status

$ boltz-api protein:design retrieve

GET/compute/v1/protein/design/{id}

Get generated protein designs

$ boltz-api protein:design list-results

GET/compute/v1/protein/design/{id}/results

Stop a running protein design run

$ boltz-api protein:design stop

POST/compute/v1/protein/design/{id}/stop

Delete protein design run data

$ boltz-api protein:design delete-data

POST/compute/v1/protein/design/{id}/delete-data

Estimate cost for a protein design run

$ boltz-api protein:design estimate-cost

POST/compute/v1/protein/design/estimate-cost

ProteinLibrary Screen

Screen an existing library of proteins against a target structure. Results are scored by binding confidence (likelihood of protein-protein interaction) and structure confidence.